Mouse Anti-Human Insulin R

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Cat-Nr.101-M514
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#2A12)
IsotypeIgG2
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of Insulin R (also called CD220) extracellular domain.
AntigenHuman recombinant Insulin R EC domain
ApplicationWB
SynonymsINSR; HHF5; CD220
DescriptionThe insulin receptor is a type I transmembrane receptor tyrosine kinase. Ligand binding results in receptor autophosphorylation, and subsequent downstream signaling important in metabolic regulation, cell growth, differentiation, and apoptosis. Mutations in the insulin receptor gene have been linked to insulin-resistant diabetes mellitus and noninsulin-dependent diabetes mellitus.
Uniprot IDP06213
Protein RefSeqNP_000199.2
mRNA RefSeqNM_000208.2

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