Rat Anti-Mouse Decorin

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Cat-Nr.103-M218
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#11F32)
IsotypeIgG2
Species ReactivityMouse
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse recombinant Decorin. The IgG2 fraction of the culture supernatant was purified by Protein A/G affinity chromatography.
Antigenrecombinant mouse Decorin
ApplicationWB
SynonymsDcn; DC; PG40; PGII; PGS2; mDcn; DSPG2; SLRR1B
DescriptionDecorin is a small secreted chondroitin/dermatan sulfate proteoglycan belonging to the class I small leucine-rich proteoglycan family (SLRP). All SLRP family members are characterized by the Nterminal and C terminal cysteine rich regions, which flank the central region containing 1012 tandem leucinerich repeats. In mouse Decorin, the glycosaminoglycan chain is Olinked to Ser34 in the Nterminal disulfide bridged loop. Decorin binds to fibronectin, TGFβ, type I and type II collagen. The binding of Decorin to these molecules is mediated via the core protein. Decorin plays a role in maintaining collagen fibrillogenesis. Depending on the cell context, Decorin can either block or augment the bioactivity of TGFβ Decorin induces growth suppression by activation of a signaling pathway that culminates in the blockade of the cell cycle machinery. Decorin can also induce fibroblast cytoskeletal and signalling changes that results in an increased cell migration (1, 2).
Uniprot IDP28654
Protein RefSeqNP_001177380.1
mRNA RefSeqNM_001190451.1

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