Rat Anti-Mouse MCPT-6

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Size100 µg
Price350 €
CategoryMonoclonal Antibody
Clone Nr.(#14F4)
ReconstitutionCentrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
AntigenRecombinant Mouse MCPT-6
ApplicationIP, N/B
SynonymsTryptase beta-2, Tryptase-2, Mast cell protease 6 (mMCP-6)
DescriptionTryptases are trypsin-like serine proteases, and beta tryptases appear to be the main isoenzymes expressed in mast cells. Mast cell protease-6 (MCP-6, MCPT6, or Tpsb2) is one of beta tryptases produced from mouse mast cells. It is stored in secretory granules of mast cells, where it forms active tetramers with heparin proteoglycan. Because of the unique arrangement of the active sites in the tetramer, which are facing a narrow central pore, Mcpt6 is resistant to macromolecular protease inhibitors. When mast cells are activated, Mcpt6 is released along with other proteins in secretory granules, participating in provoking inflammatory conditions. Mcpt6 has been implicated as a mediator in the pathogenesis of asthma and other allergic disorders in mouse models.
Uniprot IDP21845
Protein RefSeqAAA39988.1
mRNA RefSeqM57626.1

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