Mouse Anti-Human CCR2

Slide this table

Cat-Nr.101-M278
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#1J13)
IsotypeIgG2
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with 293 cells transfected with human CCR2.
AntigenHuman CCR2 transfected 293 cells
ApplicationFC
SynonymsCCR2; CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2
DescriptionCCR2 is a G-protein-linked seven transmembrane domain spanning chemokine receptor that preferentially binds monocyte chemoattractant proteins1 and 3 (MCP1 and MCP3). Two isoforms of this receptor (CCR2A and CCR2B) are expressed on cell surfaces as a result of alternate splicing from the same gene. These two CCR2 variants differ only at their intracellular carboxyl terminals, with the CCR2A form possessing 14 additional amino acids. This may provide a mechanism by which cells responding to similar extracellular ligands can activate different intracellular second messengers. Cells that respond to the action of MCP1 and therefore are likely to express CCR2 receptors, include monocytes, T cells, NK cells, basophils, mast cells and dendritic cells. A recent report suggests that B cells may also express CCR2 receptors. The recognition that a variety of chemokine receptors, including CCR2, can serve as HIV fusion cofactors and as facilitators of T cell recruitment during inflammation makes chemokine receptor monitoring an important exercise in elucidating the HIV infection process and the regulation of inflammatory reactions.
Uniprot IDP41597
Protein RefSeqNP_001116513
mRNA RefSeqNM_001123041

All prices plus VAT + possible delivery charges