Rat Anti-Mouse VEGFR-2/FLK-1

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Cat-Nr.103-M35A
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#6C23)
IsotypeIgG2a
Species ReactivityMouse
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with mouse VEGFR-2 extracellular domain. IgG2a fraction of the tissue culture supernatant was purified by Protein G affinity chromatography.
AntigenMouse VEGFR2 extra-cellular domain
ApplicationWB, IHC (P)
Synonymsvascular endothelial growth factor receptor-2 ; Kdr; Ly73; Flk-1; VEGF receptor 2; kinase insert domain protein receptor
DescriptionVEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.
Uniprot IDP35918
Protein RefSeqACJ66293.1
mRNA RefSeqEU884114

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