Mouse Anti-Human FGF-5

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Cat-Nr.101-M71
Size500 µg
Price250 €
CategoryMonoclonal Antibody
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized from PBS
BufferPBS
ReconstitutionReconstitute the antibody in sterile water to a concentration of 1.0mh/mL.
Stability and StorageThe lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
PreparationProduced in BALB/c mice using recombinant human FGF-5 as the immunizing antigen. This IgG1/K antibody was purified from a Protein A chromatography column.
AntigenRecombinant human FGF-5
ApplicationELISA, N
SynonymsFGF5; HBGF-5; Smag-82
DescriptionThe FGF family is comprised of at least seven polypeptides that are potent regulators of cell proliferation, differentiation and function. All FGFs have two conserved cysteine residues and share 30-50% sequence homology at the amino acid level. FGF5 was originally identified as a transforming gene by the NIH3T3 focus formation assay using DNA derived from human tumors. FGF5 cDNA encodes a 267 amino acid residue protein with a putative 22 amino acid residue signal peptide. The murine homologue of FGF5 was cloned and found to be 84% homologous to the human protein at the amino acid sequence level. Human and murine FGF5 exhibit cross species activity. In vitro, recombinant human FGF5 is a mitogen for Balb/3T3 fibroblasts and bovine heart endothelial cells. FGF5 was also reported to be a major muscle-derived survival factor for cultured spinal moto-neurons.
Uniprot IDP12034
Protein RefSeqNP_004455
mRNA RefSeqNM_004464

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