Rat Anti-Mouse IL-1 receptor antagonist

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Size100 µg
Price380 €
CategoryMonoclonal Antibody
Clone Nr.(#5K21)
Species ReactivityMouse
ReconstitutionCentrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of IL-1R antagonist.
Antigenrecombinant mouse protein of IL-1R antagonist
SynonymsIl1rn; IL-1ra; F630041P17Rik
DescriptionIL-1 receptor antagonist (IL-1ra) was originally isolated from the urine of patients with monocytic leukemia and has also been purified from adherent monocytes. The protein shows 26% amino acid homology to IL-1 beta and 19% homology to IL-1 alpha. It will compete with either factor for receptor binding, but does not interact with either one. Human IL-1ra will bind to both types of IL-1 receptor (I and II) on human cells. In mouse, IL-1RII does not bind IL-1ra.
Uniprot IDP25085
Protein RefSeqNP_112444.1
mRNA RefSeqNM_031167.5

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