Rat Anti-Mouse MMP-24

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Cat-Nr.103-M437
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#7J71)
IsotypeIgG2
Species ReactivityMouse
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of MMP-24 Catalytic Domain.
AntigenMouse recombinant protein of MMP-24 Catalytic Domain
ApplicationWB
SynonymsMmp24; MT5MMP; MTMMP5; MT5-MMP; AU040325
DescriptionMatrix metalloproteinase-24 or MT5-MMP is an enzyme that in humans and mouse is encoded by the MMP24 gene. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP-2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24.
Uniprot IDQ9R0S2
Protein RefSeqNP_034938.3
mRNA RefSeqNM_010808.3

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