Mouse Anti-Human VEGF-C
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Cat-Nr. | 101-MBi89 |
Size | 50 µg |
Price | 255 € |
Category | Monoclonal Antibody |
Label | Biotin |
Clone Nr. | (#107/A11) |
Isotype | IgG2a |
Species Reactivity | Human, rat |
Formulation | lyophilized |
Buffer | PBS |
Stabilizer/Carrier | BSA (50x), 0.02% sodium azide |
Reconstitution | Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. |
Stability and Storage | The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots. |
Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with recombinant human VEGF-C recombinant protein). The IgG fraction of culture supernatant was purified by Protein G affinity chromatography. |
Antigen | Recombinant human VEGF-C (RT# 300-079) |
Application | E |
Synonyms | vascular endothelial growth factor C; VEGFC; VRP; Flt4-L |
Description | VEGF-C, also known as Vascular Endothelial Growth Factor Related Protein (VRP), is a recently discovered VEGF growth factor family member that is most closely related to VEGF-D. The human VEGF-C cDNA encodes a pre-pro-protein of 416 amino acids residues. It is almost identical to the mouse VEGF-C protein. Similar to VEGF-D, VEGF-C has a VEGF homology domain spanning the middle third of the precursor molecule and long N- and C-terminal extensions. In adults, VEGF-C is highly expressed in heart, placenta, ovary and small intestine. Recombinant human VEGF-C, lacking the N- and C-terminal extensions and containing only the middle VEGF homology domain, forms primarily non-covalently linked dimers. This protein is a ligand for both VEGFR-2/KDR and VEGFR-3/FLT-4. Since VEGFR-3 is strongly expressed in lymphatic endothelial cells, it has been postulated that VEGF-C is involved in the regulation of the growth and/or differentiation of lymphatic endothelium. Although recombinant human VEGF-C is also a mitogen for vascular endothelial cells, it is much less potent than VEGF-A. The recombinant human VEGF-C contains 115 amino acids residues and was fused to a His-tag (6x His) at the C-terminal end. As a result of glycosylation VEGF-C migrates as an 18-24 kDa protein in SDS-PAGE under reducing conditions. |
Uniprot ID | P49767 |
Protein RefSeq | NP_005420.1 |
mRNA RefSeq | NM_005429.2 |
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