Rat Anti-Mouse CTLA-4

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Cat-Nr.103-M351
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#6G10)
IsotypeIgG2
Species ReactivityMouse
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of CTLA-4.
Antigenrecombinant protein of CTLA-4
ApplicationWB, FC, N
SynonymsCtla4; Cd152; Ly-56; Ctla-4
DescriptionCD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA-4 is up-regulated rapidly following T cell activation and CD28 ligation. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28.
Uniprot IDP09793
Protein RefSeqNP_033973.2
mRNA RefSeqNM_009843.3

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