Rat Anti-Mouse PIR-B

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Cat-Nr.103-M551
Size100 µg
Price350 €
CategoryMonoclonal Antibody
Clone Nr.(#3K39)
IsotypeIgG2
Formulationlyophilized
BufferPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
AntigenRecombinant Mouse PIR-B
ApplicationWB, FC
SynonymsLeukocyte immunoglobulin-like receptor, subfamily B (With TM and ITIM domains), member 3, Pirb, Lilrb3
DescriptionMouse PIR-B is a 125 kDa type I transmembrane glycoprotein with six Ig-like domains in its extracellular domain (ECD) and four ITIM-like sequences in its cytoplasmic domain. The ECD of PIR-B is highly homologous to the ECDs of multiple mouse PIR-A receptors (92-99% amino acid sequence homology), which have short cytoplasmic tails lacking ITIM motifs. PIR-A receptors have a charged residue in their transmembrane domain that facilitates interaction with ITAM-containing adaptor molecules. Whereas PIR-A receptors deliver activation signals, PIR-B can inhibit receptor-mediated activation signaling. PIR-A and PIR-B have been shown to bind various mouse MHC class I molecules. They have been proposed to be orthologs of human leukocyte immunoglobulin-like receptors.
Uniprot IDQ8R2Z1
Protein RefSeqAAH26937.1
mRNA RefSeqBC026937.1

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