Mouse Anti-Human CD105/Endoglin
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Cat-Nr. | 101-M192 |
Size | 100 µg |
Price | 380 € |
Category | Monoclonal Antibody |
Clone Nr. | (#12J64) |
Isotype | IgG1 |
Species Reactivity | Human |
Formulation | lyophilized |
Buffer | PBS |
Reconstitution | Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity. |
Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with cell membrane glycoproteins of lymphoblastic leukemia cells. IgG1 fraction of the tissue culture supernatant was purified by Protein G affinity chromatography. |
Antigen | Cell membrane proteins of leukemia cells. |
Application | Capture Ab |
Synonyms | Endoglin; END; ORW; HHT1; ORW1; CD105 |
Description | CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF-ß1 and ß3 with high affinity but not to TGF-ß2. |
Uniprot ID | P17813 |
Protein RefSeq | NP_000109 |
mRNA RefSeq | NM_000118 |
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