Rat Anti-Mouse gp-130

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Cat-Nr.103-M483
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#15D27)
IsotypeIgG2
Species ReactivityMouse
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of gp-130.
Antigenrecombinant mouse gp 130
ApplicationWB
SynonymsIl6st; CD130; gp130; AA389424; BB405851; D13Ertd699e; 5133400A03Rik
DescriptionGp130, the common signal transducing receptor component shared by the functional receptor complexes of the IL-6 family of cytokines, belongs to the classI cytokine receptor family. Binding of IL-6 or IL-11 to either the membrane-anchored or soluble IL-6 R or IL-11 R, respectively, initiates the association of IL-6 R (IL-11 R) with gp130. The complex then undergoes homodimerization and signal transduction. For other IL-6 family cytokines, such as LIF and OSM, signal transduction is similarly triggered by the heterodimerization of gp130 with LIFR or OSM R.
Uniprot IDQ00560
Protein RefSeqNP_034690.3
mRNA RefSeqNM_010560.3

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