Mouse Anti-Human Megalin
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| Cat-Nr. | 101-M144 |
| Size | 100 µg |
| Price | 275 € |
| Category | Monoclonal Antibody |
| Clone Nr. | (#CD7D5) |
| Isotype | IgG1 |
| Species Reactivity | Human, rat, mouse |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. |
| Stability and Storage | The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots. |
| Preparation | Monoclonal antibodies were produced with the help of BALB/c mice using a membrane protein fraction of isolated human glomeruli as the immunizing antigen. |
| Antigen | purified human Megalin |
| Application | IHC; IF |
| Synonyms | LRP2; DBS; GP330; low density lipoprotein receptor-related protein 2; Glycoprotein 330 |
| Description | Megalin/gp330, an approx. 600 kDa transmembrane glycoprotein is a large cell surface receptor that mediates the binding and internalization of a number of structurally and functionally distinct ligands from the lipoprotein and protease:protease inhibitor families. |
| Uniprot ID | P98164 |
| Protein RefSeq | NP_004516.2 |
| mRNA RefSeq | NM_004525.2 |
Figures
IHC staining (paraffin-embedded tissue-sections fixed in formalin) of Megalin in the brush border of the proximal tubule [Cat# 101-M144].
Immunofluorescence staining of Megalin in the brush border of the proximal tubule [Cat# 101-M144].
Reference
- NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells. Yujiro Maeoka et al., J Biol Chem. 2019 Jan 4; 294(1): 101–115.
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