Rat Anti-Mouse CD4

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Cat-Nr.103-M105
Size100 µg
Price275 €
CategoryMonoclonal Antibody
Clone Nr.(#MAB0707)
IsotypeIgG2
Species ReactivityMouse
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 400 µl sterile PBS and the final concentration is 500 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse CTL cells. IgG2 fraction of the culture supernatant was purified by Protein G affinity chromatography.
Antigenmouse CTL cells
ApplicationIHC (P), FC
SynonymsCd4; L3T4; Ly-4
DescriptionCD4 is an approximately 55 kDa type I transmembrane glycoprotein that is expressed predominantly on thymocytes and a subset of mature T cells. In humans, CD4 is also expressed to a lesser extent on monocytes and macrophage related cells.
Uniprot IDP06332
Protein RefSeqNP_038516.1
mRNA RefSeqNM_013488.2

Reference

  1. A practical approach to pancreatic cancer immunotherapy using resected tumor lysate vaccines processed to express α-gal epitopes. Kenta Furukawa et al., PLoS One. 2017; 12(10): e0184901.
  2. Fibrosis, vascular activation, and immune abnormalities resembling systemic sclerosis in bleomycin-treated Fli-1-haploinsufficient mice. Taniguchi T. et al., Arthritis Rheumatol. 2015 Feb;67(2):517-26.
  3. Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation. Yanaba K. et al., J Leukoc Biol. 2013 Oct;94(4):563-73.
  4. CD19 Expression in B Cells Regulates Atopic Dermatitis in a Mouse Model. K. Yanaba et al., Am J Pathol. 2013 Jun; 182(6): 2214–2222.

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