Mouse Anti-Human IL-5R alpha EC
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| Cat-Nr. | 101-M792 |
| Size | 100 µg |
| Price | 380 € |
| Category | Monoclonal Antibody |
| Clone Nr. | (#6J30) |
| Isotype | IgG1 |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity. |
| Antigen | Human recombinant IL-5RalphaEC domain |
| Application | WB |
| Synonyms | Interleukin-5 receptor subunit alpha, IL-5 receptor subunit alpha; IL-5R subunit alpha; IL-5R-alpha; IL-5RA, CDw125, CD125 |
| Description | Interleukin‑5 Receptor alpha (IL‑5 R alpha ), also known as CD125, is a 60 kDa hematopoietin receptor that plays a dominant role in eosinophil biology. Mature human IL‑5 R alpha consists of a 322 amino acid (aa) extracellular domain (ECD) with a WSxWS motif and a four-cysteine motif, a 20 aa transmembrane segment, and a 58 aa cytoplasmic domain. Within the ECD, human IL-5 R alpha shares 71% aa sequence identity with mouse and rat IL‑5 R alpha. Alternate splicing of human IL‑5 R alpha generates soluble secreted forms which function as IL‑5 antagonists. The high affinity receptor for IL‑5 is a complex that consists of the ligand binding IL‑5 R alpha and the transmembrane common beta chain (beta c/CD131) which is shared with the receptor complexes for IL‑3 and GM‑CSF. IL‑5 R alpha binds IL‑5 at low affinity and then associates with preformed beta c oligomers to form the signalling‑competent receptor complex. |
| Uniprot ID | Q01344 |
| Protein RefSeq | NP_000555.2 |
| mRNA RefSeq | NM_000564.4 |
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