Mouse Anti-Human VEGFR-1/Flt-1

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Cat-Nr.101-M24
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#EWC)
IsotypeIgG1
Species ReactivityHuman, mouse
Formulationlyophilized
BufferPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 1.0 mg/ml.
Stability and StorageThe lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C.
PreparationThe monoclonal antibody was produced with the help of BALB/c mice using recombinant human soluble extracellular Flt-1 (D5) as the immunizing antigen.
AntigenRecombinant human soluble Flt-1 (D5)
ApplicationELISA, WB, IF
Synonymsvascular endothelial growth factor receptor-1; FLT1; VEGF receptor 1;
DescriptionVEGFR-1 is a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.
Uniprot IDP17948
Protein RefSeqNP_001153392
mRNA RefSeqNM_001159920

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