Mouse Anti-Human IL-6

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Cat-Nr.101-M794
Size100 µg
Price350 €
CategoryMonoclonal Antibody
Clone Nr.(#4E25)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationProduced from sera of rabbits pre-immunized with highly pure (>98%) recombinant human IL-6. Anti-human IL-6 specific antibody was purified by affinity chromatography employing immobilized human IL-6 matrix.
AntigenHuman recombinant IL-6
ApplicationDetection Ab
SynonymsIL6; HGF; HSF; BSF2; IL-6; IFNB2
DescriptionIL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant human IL-6 is a 20.9 kDa protein containing 184 amino acid residues.
Uniprot IDP05231
Protein RefSeqNP_000579
mRNA RefSeqNM_000600

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