Mouse Anti-Human SNCA

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Cat-Nr.101-M637
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#7D53)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with recombinant human SNCA.
Antigenrecombinant human SNCA
ApplicationWB
SynonymsSNCA; PD1; NACP; PARK1; PARK4
DescriptionThe synuclein family (SNCA) includes synuclein-alpha, -beta, and -gamma, and synoretin. These small, highly conserved proteins are localized predominantly in the brain, concentrated in presynaptic nerve terminals. Synuclein-alpha is normally a soluble protein. Abnormal synuclein-alpha forms filamentous inclusions (Lewy bodies and Lewy neurites) in several neurodegenerative diseases, including Parkinson's disease (PD), dementia with Lewy bodies, and Alzheimer's disease. Synucleins beta and gamma (synoretin) associate with synuclein-alpha and inhibit its aggregation.
Uniprot IDP37840
Protein RefSeqNP_000336.1
mRNA RefSeqNM_000345.3

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