Mouse Anti-Human IFN alpha
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|lyophilized from PBS
|Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
|Stability and Storage
|The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
|Produced in BALB/c x ICR F1 mice using recombinant human IFN- as the immunizing antigen. IgG1 antibody was purified from ascites fluid on a Protein A affinity column.
|Recombinant human IFN-alpha
|IFNA1; IFL; IFN; IFNA; IFNA13; IFN-ALPHA; IFN-alphaD; Interferon
|Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.
- Type I interferon induces CX3CL1 (fractalkine) and CCL5 (RANTES) production in human pulmonary vascular endothelial cells. M. Nakano et al., Clin Exp Immunol. 2012 Oct; 170(1): 94–100.
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