Mouse Anti-Human BMP receptor-2

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Cat-Nr.101-M177
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#9A10)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with recombinant human BMP-R2 extra cellular domain. IgG1 fraction of the tissue culture supernatant was purified by Protein G affinity chromatography.
Antigenrecombinant human BMP RII extra cellular domain
ApplicationWB
SynonymsBMPR2; BMR2; PPH1; BMPR3; BRK-3; T-ALK; BMPR-II
DescriptionLike other members of the TGFβ superfamily, cellular responses to bone morphogenetic proteins (BMPs) have been shown to be mediated by the binding to heteromeric complex of type I and type II serine-threonine kinase receptors. Both receptor types are required for the signl transduction. BMP receptor II (BMPR II or BMPR-2) is one of the five mammalian type II receptors (including TGFβRII, ActRII, ActRIIB, BMPRII and MISRII) for the TGFβ superfamily ligands. The type II receptors for TGFβ and activin bind ligands with high affinity by itself. In contrast, BMPRII binds BMP2, BMP4 and BMP7 weakly in the absence of type I receptor, and the binding can be facilitated by the presence of the type I receptor. BMPRII mRNA is widely expressed in fetal and adult tissues. Human and mouse BMPRII are highly conserved sharing 97% sequence identity.
Uniprot IDQ13873
Protein RefSeqNP_001195.2
mRNA RefSeqNM_001204.6

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