Mouse Anti-Human VEGFR-1/Flt-1, Agonistic

Slide this table

Cat-Nr.mV1004m-h
Size200 µg
Price390 €
CategoryMonoclonal Antibody
Clone Nr.(#8F12)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 400 µl sterile PBS and the final concentration is 500 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with purified human VEGFR1 N-terminal fragment (AA N25-250)).
AntigenhVEGFR1 N-terminal fragment (N25-250)
ApplicationWB, Stimulation
Synonymsvascular endothelial growth factor receptor-1; FLT1; FLT; VEGF receptor 1
DescriptionEndothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes, dendritic cells and on trophoblast cells. The flt-1 gene was first described in 1990. The receptor contains seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular splited tyrosine kinase domain. Compared to VEGFR-2 the Flt-1 receptor has a higher affinity for VEGF but a weaker signaling activity. VEGFR-1 thus leads not to proliferation of endothelial cells, but mediates signals for differentiation. Interestingly a naturally occuring soluble variant of VEGFR-1 (sVEGFR-1) was found in HUVEC supernatants in 1996, which is generated by alternative splicing of the flt-1 mRNA. The antibody will bind near the ligand binding site of the receptor and has agonistic activity.
Uniprot IDP17948
Protein RefSeqNP_001153392
mRNA RefSeqNM_001159920

All prices plus VAT + possible delivery charges