Mouse Anti-Human Ras

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Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#8F13)
Species ReactivityHuman
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with recombinant human Ras.
Antigenrecombinant human Ras
DescriptionThe Ras proteins (HRas, NRas, and two splice variants of KRas) define a closely related family of 21 kDa GTPases that cycle between GTPbound active and GDPbound inactive states at the cytoplasmic face of the plasma membrane. Receptor tyrosine kinases and Gprotein coupled receptors activate Ras, and effectors include Raf and PI 3kinase. Activating mutations of Ras, which impair GTPase activity and stabilize the active state, are found in nearly onethird of all human cancers.
Uniprot IDP01116
Protein RefSeqNP_004976.2
mRNA RefSeqNM_004985.3

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