rat Anti-Human Cathepsin S

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Cat-Nr.101-M252
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#20B1)
IsotypeIgG2
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of Cathepsin-S.
Antigenrecombinant human Cathepsin-S
ApplicationWB
SynonymsCTSS
DescriptionCathepsin S is a lysosomal cysteine protease of the papain family. It plays a major role in the processing of the MHC class IIassociatedinvariant chain. It has been implicated in the pathogenesis of several diseases such as Alzheimer’s disease and degenerative disorders associated with the cells of the mononuclear phagocytic system. Human Cathepsin S is synthesized as a preproenzyme of 331 amino acid residues consisting a signal peptide (residues 116), a pro region (residues 17-114), and the mature enzyme (residues 115-331). Cathepsin S is less abundant in tissues than Cathepsins B, L and H. The highest levels have been found in lymph nodes, spleen, macrophages and other phagocytic cells.
Uniprot IDP25774
Protein RefSeqNP_004070
mRNA RefSeqNM_004079

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