Mouse Anti-Human Presenilin-1

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Cat-Nr.101-M608
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#7G6)
IsotypeIgG2
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with recombinant human Presenilin-1.
Antigenrecombinant human Presenilin-1
ApplicationWB, IHC (P)
SynonymsPSEN1; AD3; FAD; PS1; PS-1; S182
DescriptionPresenilin1 (PS1) is a 467 amino acid multipass lysosomal membrane protein that is a component of the gamma secretase complex. It is cleaved by endoproteolysis at or near amino acid 298 to generate N- and C- terminal fragments. Some mutations in PS 1 are associated with the risk of early onset familial Alzheimer's disease.
Uniprot IDP49768
Protein RefSeqNP_015557.2
mRNA RefSeqNM_007318.2

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