Rat Anti-Mouse ICAM-1

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Size100 µg
Price380 €
CategoryMonoclonal Antibody
Clone Nr.(#MAB0802)
Species ReactivityMouse
ReconstitutionCentrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with cytokine stimulated mouse endothelial cells. IgG fraction of the culture supernatant was purified by Protein A/G affinity chromatography. ICAM-1, a 95 kDa surface antigen found on endothelial cells, lymphocytes,epithelial cells, dendritic cells, and keratinocytes. ICAM-1 is a ligand for LFA-1 (CD11a/CD18) and MAC-1(CD11b/CD18). Its expression is up regulated upon stimulation by inflammatory mediators such as cytokines and LPS and it’s involved in B cell T-cell co- stimulatory interactions.
AntigenCytokine stimulated Mouse Endothelial cells
ApplicationIHC (P), FC
SynonymsIcam1; CD54; Ly-47; Icam-1; MALA-2
DescriptionIntercellular adhesion molecule 1 (ICAM-1), also known as CD54, binds the leukocyte integrins LFA-1 and Mac-1. ICAM-1 expression is weak on leukocytes, epithelial and resting endothelial cells, as well as some other cell types, but expression can be stimulated by IFN-gamma, TNF-alpha, IL-1 beta and LPS. Soluble ICAM-1 is found in a biologically active form in serum, probably as a result of proteolytic cleavage from the cell surface.
Uniprot IDP13597
Protein RefSeqNP_034623.1
mRNA RefSeqNM_010493.2

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