Mouse Anti-Mouse VEGFR-3/FLT-4, Antagonistic

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Size100 µg
Price625 €
CategoryMonoclonal Antibody
Clone Nr.(#9G03)
Species ReactivityMouse
ReconstitutionCentrifuge the vial prior to opening. Reconstitute the antibody with 200 µl sterile PBS and the final concentration is 500 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with mouse VEGFR3 N-terminal recombinant protein.
Antigenrecombinant mouse VEGFR3 N-terminal protein
ApplicationBlocking VEGF-C induced activiation
Synonymsvascular endothelial growth factor receptor-3; Flt4; Chy; Flt-4; VEGFR3; VEGFR-3
DescriptionVEGFR-3, also known as FLT4, is a member of the Tyr protein kinase family. The extracellular portion of VEGFR-3 contains 7 immunoglobulin (Ig)-like domains and the cytoplasmic portion contains a protein kinase domain. FLT4 regulates angiogenesis and lymphangiogenesis, its ligands are VEGF-C and D and its binding is mediated by the 2nd and 3rd Ig-like domains of FLT4. During fetal development VEGFR-3 is expressed on endothelial cells, however, in the adult mice, the vascular endothelial cells lose VEGFR-3 expression, but the lymphatic endothelium expresses it constitutively. In addition, VEGFR-3 expression can be induced in tumors with active angiogenesis.
Uniprot IDP35917
Protein RefSeqNP_032055.1
mRNA RefSeqNM_008029

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