Mouse Anti-Human CD105/Endoglin, Antagonistic

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Size100 µg
Price625 €
CategoryMonoclonal Antibody
Clone Nr.(#7D11)
Species ReactivityHuman
ReconstitutionCentrifuge the vial prior to opening. Reconstitute the antibody with 200 µl sterile PBS and the final concentration is 500 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with purified human extracellular domain of Endoglin.
Antigenhuman endoglin extra-cellular domain
ApplicationBlocking TGF-beta1 induced threonine/serine phosphorylation of endoglin
SynonymsEndoglin; END; ORW; HHT1; ORW1; CD105
DescriptionEndoglin, also known as CD105, is a type I integral transmembrane glycoprotein and is an accessory receptor for TGF-beta superfamily ligands. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages.
Uniprot IDP17813
Protein RefSeqNP_000109
mRNA RefSeqNM_000118

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