Mouse Anti-Human IL-18 (IL-1F4)

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Size100 µg
Price350 €
CategoryMonoclonal Antibody
Clone Nr.(#42U51
Species ReactivityHuman
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
AntigenRecombinant human IL-18 (IL-1F4)
SynonymsInterleukin-18, Iboctadekin, Interferon gamma-inducing factor, (IFN-gamma-inducing factor), Interleukin-1 gamma (IL-1 gamma)
DescriptionInterleukin-18 (IL-18) is a proinflammatory cytokine in the IL-1 family that exerts distinct immune effects depending on the local cytokine environment. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, gamma δT cells, and phagocytes. The precursor is activated intracellularly by Caspase-1 mediated proteolysis to release the 17 kDa mature cytokine. The precursor can also be released by necrotic cells for extracellular cleavage by multiple proteases. IL-18 activation is induced by infection or tissue damage and contributes to disease pathology in chronic inflammation. IL-18 binds to the widely expressed IL-18 R alpha which recruits IL-18 R beta to form the signaling receptor complex. Its bioactivity is negatively regulated by interactions with IL-18 binding proteins and virally encoded IL-18BP homologs.
Uniprot IDQ14116
Protein RefSeqNP_001230140.1
mRNA RefSeqNM_001243211.1

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