Mouse Anti-Human ICAM-1

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Cat-Nr.101-M97
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#7D22)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with human ICAM-1 N-terminal recombinant protein). The IgG1 fraction of culture supernatant was purified by Protein G affinity chromatography.
Antigenrecombinant human ICAM1 N-terminal protein
ApplicationELISA, WB, IHC (Formalin/P)
SynonymsICAM1; BB2; CD54; P3.58
DescriptionICAMs are members of the Ig superfamily of calcium-independent transmembrane glycoproteins. ICAM-1 is a ligand for lymphocyte function-associated (LFA) and Mac-1 integrins and the major human rhinovirus receptor. The primary function of ICAM-1 is to provide adhesion between endothelial cells and leukocytes after stress or injury. The human ICAM-1 gene codes for a 505 amino acid transmembrane glycoprotein containing a 29 amino acid cytoplasmic domain, a 23 amino acid transmembrane domain, and a 453 amino acid extracellular domain. Recombinant human ICAM-1 is a 49.5 kDa glycoprotein comprising the extracellular domain (453 amino acid residues) of ICAM-1. Monomeric glycosylated ICAM-1 migrates at an apparent molecular weight of approximately 72.0-80.0 kDa by SDS-PAGE analysis under reducing conditions.
Uniprot IDP05362
Protein RefSeqNP_000192.2
mRNA RefSeqNM_000201

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