Mouse Anti-Human ADAM-17

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Cat-Nr.101-M207
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#8C13)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with recombinant human ADAM17, also called TACE.
Antigenrecombinant human ADAM-17, also called TACE
ApplicationWB, FC
SynonymsADAM17; CSVP; TACE; NISBD; ADAM18; CD156B
DescriptionThe gene for the antigen encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.
Uniprot IDP78536
Protein RefSeqNP_003174
mRNA RefSeqNM_003183

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