Mouse Anti-Human HAI-1

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Cat-Nr.101-M445
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#3X28)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of HAI-1 extracellular domain.
Antigenrecombinant human HAI-1 EC domain
ApplicationWB, N
SynonymsSPINT1; HAI; HAI1; MANSC2
DescriptionHAI1 is a Kunitz-type serine protease inhibitor, identified as a strong inhibitor of HGF activator (HGFA) and matriptase. The membrane anchored HAI1 consists of two Kunitz domains, a LDL receptorlike domain, and a C-terminal transmembrane domain. Two soluble forms are generated by ectodomain shedding, one with a single Kunitz domain and the other with two Kunitz domains. HAI1 is not only an inhibitor but also a specific receptor of active HGFA, acting as a reservoir of this enzyme on the cell surface . The shedding of HAI1 and HGFA/HAI1 complex is enhanced by treatment with phorbol 12-myristate 13-acetate or IL1β. The regulated shedding is completely inhibited by a synthetic zinc metalloprotease inhibitor.
Uniprot IDO43278
Protein RefSeqNP_857593.1
mRNA RefSeqNM_181642.2

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