Mouse Anti-Human Lyve-1
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|Reconstitution||Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.|
|Stability and Storage||Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.|
|Preparation||This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with human recombinant LYVE-1 protein (Extracellular domain).The IgG2 fraction of the tissue culture supernatant was purified by Protein G affinity chromatography.|
|Antigen||Human recombinant LYVE-1|
|Synonyms||LYVE1; HAR; XLKD1; LYVE-1; CRSBP-1|
|Description||LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.|
- Angiotensin II Type 1 Receptor (AT-1R) Expression Correlates with VEGF-A and VEGF-D Expression in Invasive Ductal Breast Cancer. A. Jethon et al., Pathol Oncol Res. 2012 Oct; 18(4): 867–873.
- Endothelin-1 stimulates lymphatic endothelial cells and lymphatic vessels to grow and invade. F. Spinella et al., Cancer Res. 2009 Mar 15;69(6):2669-76.
- Adventitial lymphatics of internal carotid artery in healthy and atherosclerotic vessels. K. Drozdz et al., Folia Histochem Cytobiol. 2008;46(4):433-6.
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