Mouse Anti-Human Lyve-1

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Cat-Nr.101-M130
Size100 µg
Price275 €
CategoryMonoclonal Antibody
Clone Nr.(#7F13)
IsotypeIgG2
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with human recombinant LYVE-1 protein (Extracellular domain).The IgG2 fraction of the tissue culture supernatant was purified by Protein G affinity chromatography.
AntigenHuman recombinant LYVE-1
ApplicationWB, IHC
SynonymsLYVE1; HAR; XLKD1; LYVE-1; CRSBP-1
DescriptionLYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
Uniprot IDQ9Y5Y7
Protein RefSeqNP_006682
mRNA RefSeqNM_006691

Reference

  1. Angiotensin II Type 1 Receptor (AT-1R) Expression Correlates with VEGF-A and VEGF-D Expression in Invasive Ductal Breast Cancer. A. Jethon et al., Pathol Oncol Res. 2012 Oct; 18(4): 867–873.
  2. Endothelin-1 stimulates lymphatic endothelial cells and lymphatic vessels to grow and invade. F. Spinella et al., Cancer Res. 2009 Mar 15;69(6):2669-76.
  3. Adventitial lymphatics of internal carotid artery in healthy and atherosclerotic vessels. K. Drozdz et al., Folia Histochem Cytobiol. 2008;46(4):433-6.

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