Rat Anti-Mouse Frizzled-2

Slide this table

Size100 µg
Price380 €
CategoryMonoclonal Antibody
Clone Nr.(#7D14)
Species ReactivityMouse
ReconstitutionCentrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of Frizzled 2.
Antigenrecombinant mouse protein Frizzled 2
SynonymsFzd2; Fz10; Fzd10; Mfz10; Mfz10a; AL033370; AW456835
DescriptionWnt signaling is involved in variety of developmental processes including cell fate determination, cell polarity, tissue patterning and control of cell proliferation. Members of the Frizzled family of proteins serve as receptors for the Wnt signaling pathway. The founding member of this family was identified in Drosophila based on its role in tissue polarity in the adult cuticle and named for the disorganized appearance of bristle hairs on the mutant. Ten mammalian Frizzled genes have been identified to date. The predicted structure of Frizzled proteins is similar among all family members, containing a divergent Nterminal signal peptide, a highly conserved extracellular cysteinerich domain, a variablelength linker region, a sevenpass transmembrane domain, and a variablelength C-terminal tail. One of the most conserved regions of the Frizzled proteins is the extracellular cysteine-rich domain (CRD) which spans approximately 120 AA and contains 10 invariant cysteines. Mouse Frizzled-2 shows 100% amino acid identity to human and rat Frizzled2 in the CRD region. Frizzled2 expression is greater in embryonic than adult tissues, with heart, brain, lung, kidney and gut showing the highest levels.
Uniprot IDQ9JIP6
Protein RefSeqNP_065256.1
mRNA RefSeqNM_020510.2

All prices plus VAT + possible delivery charges