Mouse Anti-Human Macroglobulin alpha 2
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| Cat-Nr. | 101-M560 |
| Size | 100 µg |
| Price | 380 € |
| Category | Monoclonal Antibody |
| Clone Nr. | (#4H44) |
| Isotype | IgG1 |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with Human a-2 macroglobulin recombinant protein. |
| Antigen | Human recombinant alpha-2 macroglobulin |
| Application | WB |
| Synonyms | A2M; A2MD; CPAMD5; FWP007; S863-7 |
| Description | Human α2macroglobulin (hα2M) is a serum glycoprotein that has sequence similarity to other members of the α2M family including complement components C3, C4 and C5. α2M is synthesized as a polypeptide of 1474 amino acids with a signal peptide (23 residues). The mature protein is a tetramer (720 kDa) of 4 identicalsubunits (180 kDa), which form two disulfide bondlinked-dimers. As a general and irreversible protease inhibitor implicated in many processes, α2M is able to inhibit all four classes of proteases by a unique trapping mechanism. The bait region of hα2M (residues 690-728) contains specific cleavage sites for different proteases. The cleavage of the bait region by a protease induces a conformation change in α2M, which then traps and forms a covalent bond with the protease. The trapped protease remains active against small peptide substrates but loses its ability to interact with large protein substrates or inhibitors. |
| Uniprot ID | P01023 |
| Protein RefSeq | NP_000005.2 |
| mRNA RefSeq | NM_000014.4 |
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