Mouse Anti-Human Macroglobulin alpha 2

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Size100 µg
Price380 €
CategoryMonoclonal Antibody
Clone Nr.(#4H44)
Species ReactivityHuman
ReconstitutionCentrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with Human a-2 macroglobulin recombinant protein.
AntigenHuman recombinant alpha-2 macroglobulin
SynonymsA2M; A2MD; CPAMD5; FWP007; S863-7
DescriptionHuman α2macroglobulin (hα2M) is a serum glycoprotein that has sequence similarity to other members of the α2M family including complement components C3, C4 and C5. α2M is synthesized as a polypeptide of 1474 amino acids with a signal peptide (23 residues). The mature protein is a tetramer (720 kDa) of 4 identicalsubunits (180 kDa), which form two disulfide bondlinked-dimers. As a general and irreversible protease inhibitor implicated in many processes, α2M is able to inhibit all four classes of proteases by a unique trapping mechanism. The bait region of hα2M (residues 690-728) contains specific cleavage sites for different proteases. The cleavage of the bait region by a protease induces a conformation change in α2M, which then traps and forms a covalent bond with the protease. The trapped protease remains active against small peptide substrates but loses its ability to interact with large protein substrates or inhibitors.
Uniprot IDP01023
Protein RefSeqNP_000005.2
mRNA RefSeqNM_000014.4

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