Mouse Anti-Human VEGFR-2/KDR

Slide this table

Cat-Nr.101-M34
Size100 µg
Price255 €
CategoryMonoclonal Antibody
Clone Nr.(#4(20I6))
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Stability and StorageThe lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
PreparationThe monoclonal antibody was produced with the help of BALB/c mice using recombinant human soluble extracellular KDR (110 kDa) as the immunizing antigen. Mouse IgG1 antibody (clone 4 (20I6)) from hybridomas was purified from cell culture supernatant by Protein G chromatography.
Antigenrecombinant human soluble extracellular KDR (D7)
ApplicationELISA, WB, IHC, IF, FC
Synonymsvascular endothelial growth factor receptor-2 ; KDR; FLK1; CD309; VEGF receptor 2; VEGFR2; kinase insert domain protein receptor
DescriptionVEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. Human VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.
Uniprot IDP35968
Protein RefSeqNP_002244.1
mRNA RefSeqNM_002253.2

Figures


Reference

  1. Similarities Between Stem Cell Niches in Glioblastoma and Bone Marrow: Rays of Hope for Novel Treatment Strategies. V.V.V. Hira et al., J Histochem Cytochem. 2020 Jan; 68(1): 33–57.
  2. Similarities and differences of human and experimental mouse lymphangiomas. Kasten P. et al., Dev Dyn. 2007 Oct;236(10):2952-61.

All prices plus VAT + possible delivery charges