Rat Anti-Mouse ALS

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Cat-Nr.103-M304
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#4K23)
IsotypeIgG1
Species ReactivityMouse
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of ALS.
Antigenrecombinant protein of ALS
ApplicationWB
SynonymsIgfals; ALS; Albs; mKIAA4111
DescriptionALS (Acid labile subunit) is an 84-86 kDa glycoprotein member of the leucine rich repeat superfamily of molecules. It is secreted by hepatocytes in response to growth hormone stimulation, and forms a 140-150 kDa ternary complex with IGFBP3 (or IGFBP5) and IGFI. This complex increases the half-life of IGFI and retains it in the circulation for use in multiple tissues. Mature mouse ALS is 580 amino acids (aa) in length (aa 24-603). It contains twentyone 20-23 aa LRRs that participate in proteinprotein interactions. There are two potential isoform variants that show N-terminal extensions. One contains a 66 aa substitution for aa 1 -5, while another possesses an 89 aa substitution again for aa 15. Over aa 28-603, mouse ALS shares 79% and 93% aa identity with human and rat ALS, respectively.
Uniprot IDP70389
Protein RefSeqNP_032366.2
mRNA RefSeqNM_008340.3

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