Mouse Anti-Human Furin

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Cat-Nr.101-M423
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#4G31)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of Furin.
Antigenrecombinant human Furin
ApplicationWB, IHC (P)
SynonymsFURIN; FUR; PACE; SPC1; PCSK3
DescriptionFurin is a member of the proprotein convertase (PC) family, which belongs to the subtilisin superfamily of serine protease. As a cellular protease, Furin processes a variety of proproteins in secretory pathway compartments by cleaving after ArgXaaLys/ ArgArglike motifs, which usually reside at the end of the pro regions of these proproteins. Examples of the proprotein substrates are growth factors and receptors, extracellular matrix proteins, and other proteases. Furin has an essential role in embryogenesis and homeostasis and is implicated in various pathologies such as cancer, neurodegenerative diseases and anthrax. It is synthesized as a 794 amino acid type I transmembrane protein precursor with a signal peptide (residues 124), a pro region (residues 25-107), which play a crucial role in the folding, activation and transport of Furin, and a mature chain (residues 108-794). The mature chain consists of the subtilisin-like catalytic domain, a P domain, which is essential for enzyme activity and the modulation of pH and calcium requirements, and a cytoplasmic domain, which controls the localization and sorting of Furin in the transGolgi network/endosomal system. The purified recombinant human Furin (residues 108-715) corresponds to the mature enzyme terminated before the transmembrane domain.
Uniprot IDP09958
Protein RefSeqNP_002560.1
mRNA RefSeqNM_002569.2

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