Mouse Anti-Human Trophoblast glycoprotein (5T4)

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Cat-Nr.101-M853
Size100 µg
Price350 €
CategoryMonoclonal Antibody
Clone Nr.(#7A11)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
AntigenRecombinant human 5T4
ApplicationIHC, FC
Synonyms5T4 oncofetal trophoblast glycoprotein, 5T4, 5T4-AG, 5T4M6P1,5T4 oncofetal antigen, TPBG, trophoblast glycoprotein
DescriptionTrophoblast glycoprotein, also known as TPBG, 5T4, Wnt-Activated Inhibitory Factor 1 or WAIF1, is a human protein encoded by a TPBG gene.[5] TPBG is an antagonist of Wnt/β-catenin signalling pathway. 5T4 is an antigen expressed in a number of carcinomas. It is an N-glycosylated transmembrane 72 kDa glycoprotein containing eight leucine-rich repeats. 5T4 is often referred to as an oncofetal antigen due to its expression in foetal trophoblast (where it was first discovered) or trophoblast glycoprotein (TPBG). 5T4 is found in tumors including the colorectal, ovarian, and gastric. Its expression is used as a prognostic aid in these cases. It has very limited expression in normal tissue but is widespread in malignant tumours throughout their development. One study found that 5T4 was present in 85% of a cohort of 72 colorectal carcinomas and in 81% of a cohort of 27 gastric carcinomas.
Uniprot IDQ13641
Protein RefSeqNP_001159864.1
mRNA RefSeqNM_001166392.1

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