Mouse Anti-Human BMP-6

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Cat-Nr.101-M237
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#10H10)
IsotypeIgG2
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of Bone Morphogenetic Protein 6 (BMP-6).
Antigenrecmombinant human BMP-6
ApplicationWB, N
SynonymsBMP6; VGR; VGR1
DescriptionHuman BMP6 is one of at least 15 structurally and functionally related BMPs, which are members of the transforming growth factor β (TGFβ) superfamily. BMPs were originally identified as protein regulators of cartilage and bone formation. However, they have since been shown to be involved in embryogenesis and morphogenesis of various tissues and organs. BMPs have also been shown to regulate the growth, differentiation, chemotaxis, and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells, and neuronal cells. Similarly to other TGFβ family proteins, BMPs are highly conserved across animal species. At the amino acid sequence level, mature human and mouse BMP6 shares 96% amino acid sequence identity. BMP6 is synthesized as a large precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxyterminal domain. Biologically active BMP 6is a disulfidelinked homodimer of the carboxyterminal 132 amino acid residues that contains the characteristic seven conserved cysteine residues involved in the formation of the cysteine knot and the single interchain disulfide bond. Cellular responses to BMP6 have been shown to be mediated by the formation of heterooligomeric complexes of type I and type II serine/threonine kinase receptors. Based on amino acid sequence similarity, BMP 5, 6, 7, and 8 are in the same subgroup.
Uniprot IDP22004
Protein RefSeqNP_001709
mRNA RefSeqNM_001718

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