Mouse Anti-Human Gi24 (B7-H5, VISTA, PD-1H)

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Cat-Nr.101-M758
Size100 µg
Price350 €
CategoryMonoclonal Antibody
Clone Nr.(#29N17)
IsotypeIgG2
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
AntigenRecombinant human Gi24 (B7-H5, VISTA, PD-1H)
ApplicationICC, FC
SynonymsV-type immunoglobulin domain-containing suppressor of T-cell activation, Platelet receptor Gi24, Stress-induced secreted protein-1 (Sisp-1), V-set domain-containing immunoregulatory receptor, V-set immunoregulatory receptor
DescriptionVISTA (V-domain immunoglobulin suppressor of T cell activation) is an immune checkpoint receptor expressed primarily on the surface of hematopoietic cells. Specifically, VISTA is expressed on naïve CD4+ T cells and regulatory T cells. And it is up regulated in vivo on activated monocytes and dendritic cells. VISTA inhibits CD4+ and CD8+ T cell proliferation, and their production of the proinflammatory cytokines IL 2 and IFN gamma. VISTA protein is also observed on the surface of cancer cells and attenuates the anti tumor immune response enabling tumor progression. VISTA, also known as B7 H5, PD-1H, Platelet receptor Gi24, Dies1, and SISP1, is a 55 65 kDa transmembrane glycoprotein with homology to B7 like immune co stimulatory molecules.
Uniprot IDQ9H7M9
Protein RefSeqNP_071436.1
mRNA RefSeqNM_022153.1

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