Mouse Anti-Human gp-130

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Cat-Nr.101-M441
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#9X23)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of gp130 (also called CD130).
Antigenrecombinant human gp 130
ApplicationWB
SynonymsIL6ST; CD130; GP130; CDW130; IL-6RB
DescriptionGp130, the common signal transducing receptor component shared by the functional receptor complexes of the IL-6 family of cytokines, belongs to the classI cytokine receptor family. Binding of IL-6 or IL-11 to either the membrane-anchored or soluble IL-6 R or IL-11 R, respectively, initiates the association of IL-6 R (IL-11 R) with gp130. The complex then undergoes homodimerization and signal transduction. For other IL-6 family cytokines, such as LIF and OSM, signal transduction is similarly triggered by the heterodimerization of gp130 with LIFR or OSM R.
Uniprot IDP40189
Protein RefSeqNP_786943.1
mRNA RefSeqNM_175767.2

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