Mouse Anti-Human IL-10 receptor alpha

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Cat-Nr.101-M472
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#7Q35)
IsotypeIgG2
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of IL-10 Ra extracellular domain.
Antigenrecombinant human IL-10 Rbalpha EC domain
ApplicationWB
SynonymsIL10RA; CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1
DescriptionHuman and mouse IL-10 receptors are structurally related to the IFN-gamma receptor. These receptors are members of the class II subgroup of the cytokine receptor superfamily. The deduced amino acid sequence of human IL-10 R is approximately 60% identical to mouse IL-10 R. Although human IL-10 has cross-species activities and is active on mouse cells, mouse IL-10 is species-specific in its actions and does not bind to the human IL-10 receptor. The human IL-10 R gene has been mapped to chromosome 11q23.3. Recombinant IL-10 soluble receptor, consisting of the extracellular domain of IL-10 R, binds IL-10 with high affinity in solution and is a potent IL-10 antagonist.
Uniprot IDQ13651
Protein RefSeqNP_001549.1
mRNA RefSeqNM_001558.3

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