Mouse Anti-Human IL-2 receptor, soluble

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Size500 µg
Price275 €
CategoryMonoclonal Antibody
IsotypeIgG2a, kappa
Species ReactivityHuman
Formulationlyophilized from PBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Stability and StorageThe lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
PreparationProduced in mice using highly pure (>98%) recombinant human soluble IL-2 Receptor alpha as the immunizing antigen. This IgG2aK antibody was purified from cell culture by Protein G affinity chromatography.
AntigenRecombinant Human sIL-2 Receptor α
ApplicationELISA, WB, N
SynonymsIL-2 receptor, soluble
DescriptionHuman IL-2 exerts its biological effects via signaling through its receptor system, IL-2R. IL-2 and its receptor (IL-2R) are required for T-cell proliferation and other fundamental functions which are crucial of the immune response. IL-2R consists of 3 noncovalently linked type I transmembrane proteins which are the alpha (p55), beta (p75), and gamma (p65) chains. The IL-2R alpha chain contains an extracellular domain of 219 amino acids, a transmembrane domain of 19 amino acids, and an intracellular domain of 13 amino acids. The secreted extracellular domain of IL-2R alpha (s-IL-2R-a), also called TAC-antigen, is expressed on leukemia cells, lymphoma cells, approximately 10% NK cells, as well as recently activated T and B cells. Recombinant human s-IL-2R-a is a 24.8 kDa protein containing 219 amino acid residues consisting of only the extracellular domain of IL-2R alpha. Due to glycosylation, IL-2R alpha has an approximate molecular weight of 31 kDa based on SDS-PAGE gel and Mass Spectrometry.
Uniprot IDP01589
Protein RefSeqNP_000408.1
mRNA RefSeqNM_000417.2

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