Rat Anti-Mouse VEGFR-3/FLT-4

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Cat-Nr.103-M38
Size100 µg
Price275 €
CategoryMonoclonal Antibody
Clone Nr.(#5F63)
IsotypeIgG2
Species ReactivityNo cross reactivity to mouse VEGFR-1 and VEGFR-2. Cross reactivity to other species has not been tested!
Formulationlyophilized
BufferPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse VEGFR-3 extracellular domain. IgG fraction of the tissue culture supernatant was purified by Protein G affinity chromatography.
AntigenMouse VEGFR-3 extracellular domain
ApplicationWB, IHC (P)
Synonymsvascular endothelial growth factor receptor-3; Flt4; Chy; Flt-4; VEGFR-3;
DescriptionReceptor tyrosine kinase VEGFR-3, also known as Flt-4, together with VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1), are the receptors for vascular endothelial growth factors (VEGF). The VEGFR family belongs to the class II subfamily of receptor tyrosine kinases (RTKs), containing a large extracellular region which is composed of seven Ig-like domains (D1–D7), a single transmembrane (TM) helix and cytoplasmic region with a tyrosine kinase activity. In VEGFR-3, the fifth Ig homology domain is proteolytically cleaved which results in polypeptides remaining linked by two disulfide bonds. VEGFR-3 is widely expressed on all endothelial cells in early embryogenesis, while, in adult tissues, VEGFR-3 expression disappears from the vascular endothelial cells and is observed only on the lymphatic endothelium. VEGF-C and VEGF-D activation of VEGFR-3 plays an important role in the formation of the lymphatic vessel system.
Uniprot IDP35917
Protein RefSeqNP_032055.1
mRNA RefSeqNM_008029

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