Rat Anti-Mouse Oncostatin M

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Cat-Nr.103-M446
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#7H61)
IsotypeIgG2
Species ReactivityMouse
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of Oncostatin-M.
Antigenrecombinant mouse Oncostatin
ApplicationWB
SynonymsOSM
DescriptionOncostatin M (OSM) is a member of the IL-6 family of cytokines that is produced primarily by activated T cells and macrophages. OSM induces fibroblast proliferation, inhibits tumor cell proliferation, and plays a role in immune regulation. Mouse OSM binds to the OSM receptor β (OSMRβ) which forms a heteromeric complex with the common IL-6 family receptor subunit, gp130. In contrast, human OSM binds to two distinct receptor complexes, the OSMRβ/gp130 and LIFRβ/gp130 complexes. The ability of human OSM to bind to two receptors may explain the overlapping and distinct activities of human OSM and LIF. OSM induces the activation the JAK2, STAT3, and ERK1/2 pathways.
Uniprot IDP53347
Protein RefSeqNP_001013383.1
mRNA RefSeqNM_001013365.2

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