Mouse Anti-Human BACE-1

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Cat-Nr.101-M227
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#6J26)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of the extracellular domain of beta-site APP (Cleavage of amyloid precursor protein) cleaving enzyme (also called BACE-1).
Antigenrecombinant human recombinant BACE-1 (EC domain)
ApplicationWB, IHC (P)
SynonymsBACE1; ASP2; BACE; HSPC104
DescriptionCleavage of amyloid precursor protein (APP) into 40 or 42 amino acid amyloid β (aβ) peptides is a result of the action of two proteases β- and γ-secretase. The beta-site APP cleaving enzyme, or BACE-1, is a transmembrane aspartic protease that is localized in the Golgi and endosomes. Low levels of BACE-1 mRNA are found in most adult tissues with a higher level of expression in pancreas.
Uniprot IDP56817
Protein RefSeqNP_036236.1
mRNA RefSeqNM_012104.4

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