Mouse Anti-Human CD80

Slide this table

Cat-Nr.101-M315
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#6N36)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of CD 80 (also called B7-1).
AntigenHuman recombinant CD80 EC domian
ApplicationIHC, FC, N
SynonymsCD80; B7; BB1; B7-1; B7.1; LAB7; CD28LG; CD28LG1
DescriptionB7-1(CD80) and B7-2, together with their receptors CD28 and CTLA4, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the downregulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be upregulated through interferon gamma. B7-1 and B7-2 are both members of the Immunoglobulin superfamily.
Uniprot IDP33681
Protein RefSeqNP_005182.1
mRNA RefSeqNM_005191.3

All prices plus VAT + possible delivery charges