Rat Anti-Mouse Stem Cell Antigen 1/Sca-1

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Size100 µg
Price350 €
CategoryMonoclonal Antibody
Clone Nr.(#2M39)
Species ReactivityMouse
ReconstitutionCentrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of Sca-1.
AntigenMouse recombinant protein of Sca-1
ApplicationIHC (F)
SynonymsLy6a; TAP; Sca1; Sca-1; Ly-6A.2; Ly-6A/E; Ly-6E.1
DescriptionSca-1 is an 18 kDa phosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly-6) family. Sca-1 is encoded by the strain-specific Ly-6 E/A allelic gene. Its expression on multipotent hematopoietic stem cells (HSC) has been used as a marker of HSCs in mice of both Ly-6 haplotypes. Sca-1-positive HSCs can be found in the adult bone marrow, fetal liver, and mobilized peripheral blood and spleen in the adult animal. However, Sca-1 has also been discovered in several non-hematopoietic tissues and can be used to enrich other progenitor cell populations as well. It is suggested that Sca-1 could be involved in regulating both B and T cell activation.
Uniprot IDP05533.1
Protein RefSeqNP_034868.1
mRNA RefSeqNM_010738.3

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