Rat Anti-Mouse Cathepsin D

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Cat-Nr.103-M315
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#7D22)
IsotypeIgG2
Species ReactivityMouse
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of Cathepsin-D.
Antigenrecombinant mouse Cathepsin-D
ApplicationWB
SynonymsCtsd; CD; CatD
DescriptionCathepsin D is a lysosomal aspartic protease of the pepsin family. Mouse Cathepsin D is synthesized as a precursor protein, consisting of a signal peptide (residues 120), a propeptide (residues 21-64), and a mature chain (residues 65-410). It is expressed in most cells and overexpressed in breast cancer cells. It is a major enzyme in protein degradation in lysosomes, and also involved in the presentation of antigenic peptides. Mice deficient in this enzyme showed a progressive atrophy of the intestinal mucosa, a massive destruction of lymphoid organs, and a profound neuronal ceroid lipofucinosis, indicating that Cathepsin D is essential for proteolysis of proteins regulating cell growth and tissue homeostasis. Cathepsin D secreted from human prostate carcinoma cells is responsible for the generation of angiostatin, a potent endogeneous inhibitor of angiogenesis.
Uniprot IDP18242
Protein RefSeqNP_034113
mRNA RefSeqNM_009983

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