Mouse Anti-Human TGF-beta1

Slide this table

Cat-Nr.101-M85
Size500 µg
Price250 €
CategoryMonoclonal Antibody
IsotypeIgG1, kappa
Species ReactivityHuman
Formulationlyophilized from PBS
BufferPBS
ReconstitutionReconstitute the antibody in sterile water to a concentration of 1.0mg/mL.
Stability and StorageThe lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
PreparationProduced from a hybridoma using purified recombinant, insect cell derived, hTGF-beta-1. This IgG1k antibody was purified on a Protein G affinity column.
AntigenRecombinant human TGF-beta1
ApplicationELISA, WB
SynonymsLTBP1
DescriptionTransforming Growth Factor Beta 1, 2, and 3 (TGF-beta 1, TGF-beta 2, and TGF-beta 3) are highly pleiotropic cytokines that virtually all cell types secrete. TGF-beta molecules are proposed to act as cellular switches that regulate processes such as immune function, proliferation, and epithelial-mesenchymal transition. Targeted deletions of these genes in mice show that each TGF-beta isoform has some non-redundant functions: TGF-beta 1 is involved in hematopoiesis and endothelial differentiation; TGF-beta 2 affects development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems; and TGF-beta 3 influences palatogenesis and pulmonary development. The full range of in vitro biological activities of TGF-beta 5 has not yet been explored. However, TGF-beta 1, TGF-beta 2, TGF-beta 3, and TGF-beta 5 have been found to be largely interchangeable in an inhibitory bioassay, and it is anticipated that TGF-beta 5 will show a spectrum of activities similar to the other TGF-beta family members. To date, the production of TGF-beta 5 has only been demonstrated in Xenopulos.
Uniprot IDP01137
Protein RefSeqNP_000651.1
mRNA RefSeqNM_000660.4

All prices plus VAT + possible delivery charges